Treadmill exercise rescues motor deficits in parkinsonian mice by modulating striatal D2-MSN activity: evidence from calcium imaging and chemogenetics

ObjectiveThe aim of this study is to investigate whether treadmill exercise alleviates motor dysfunction in a mouse model of Parkinson’s disease (PD) by modulating the excitability of striatal medium spiny neurons expressing dopamine type 2 receptors (D2-MSNs).MethodsA unilateral 6-hydroxydopamine (...

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Principais autores:	Ping Chen, Yuan Zeng, Bing Liu, Quan Yang, Wan Chun Xue, Nanlin Liu, Chunyu Zhuang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Systems Neuroscience
Assuntos:	behavioral dysfunction dopamine type-2 receptor exercise medium spiny neurons Parkinson’s disease striatum
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnsys.2026.1851618/full
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