Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

Abstract Background The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heritability remains unexplained. Polygenic risk scores...

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主要な著者:	Laura Ibanez, Umber Dube, Benjamin Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L. Del-Aguila, Albert A. Davis, Joel S. Perlmutter, Oscar Harari, Bruno A. Benitez, Carlos Cruchaga
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2017-11-01
シリーズ:	BMC Neurology
主題:	Parkinson disease Genetics Age at onset Biomarkers Polygenic risk score
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12883-017-0978-z
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