Radiation-induced severe lymphopenia predicts distant metastasis in rectal cancer: dosimetric implications for immune-sparing radiotherapy

Abstract Background Lymphopenia is a frequent complication of pelvic radiotherapy and may impair systemic immune surveillance. This study aimed to evaluate the prognostic impact of acute severe lymphopenia (ASL) in rectal cancer and to identify dosimetric predictors relevant to immune-sparing radiot...

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Hlavní autoři:	Yi-Chiao Cheng, Wen-Yen Huang, Po-Chien Shen, Fu-Mei Chen, Meei-Shyuan Lee, Jen-Fu Yang, Hao-Cheng Chang, Wei-Chou Chang, Jia-Hong Chen, Cheng-Hsiang Lo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-01-01
Edice:	Radiation Oncology
Témata:	Rectal cancer Radiation-induced lymphopenia Distant metastasis Pelvic bone marrow Immune-sparing radiotherapy Dosimetric analysis
On-line přístup:	https://doi.org/10.1186/s13014-026-02791-3
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