Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.

UNLABELLED: THE BACKGROUND: Ribonuclease L (RNASEL), encoding the 2'-5'-oligoadenylate (2-5A)-dependent RNase L, is a key enzyme in the interferon induced antiviral and anti-proliferate pathway. Mutations in RNASEL segregate with the disease in prostate cancer families and specific genotypes are ass...

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Principais autores:	Bo Eskerod Madsen, Eliana Marisa Ramos, Mathieu Boulard, Katarzyna Duda, Jens Overgaard, Marianne Nordsmark, Carsten Wiuf, Lise Lotte Hansen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2008-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC2424240?pdf=render
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