Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response

Retinal ganglion cells (RGCs), the projection neurons of the eye, are irreversibly lost once the optic nerve is injured, which is a critical mechanism of glaucoma. Mobile zinc (Zn²⁺) levels rapidly increase in retinal interneuron amacrine cells and Zn²⁺ is then transferred to R...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Jiahui Tang, Zhe Liu, Jiaxu Han, Jingfei Xue, Liyan Liu, Jicheng Lin, Caiqing Wu, Qi Zhang, Siting Wu, Canying Liu, Haishun Huang, Yuanyuan Fu, Min Li, Yehong Zhuo, Yiqing Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-10-01
Serie:	Antioxidants
Soggetti:	optic nerve injury retinal ganglion cells zinc mitochondria ISR
Accesso online:	https://www.mdpi.com/2076-3921/11/10/2001
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!