Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling

Mutations in presenilin-1 (PS1), the leading cause of early-onset, autosomal-dominant familial Alzheimer's disease (FAD), enhance calcium signaling mediated by inositol 1,4,5-trisphosphate (IP3). To elucidate the subcellular mechanisms underlying this enhancement, we used high resolution line-scanni...

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Détails bibliographiques

Auteurs principaux:	Malcolm A. Leissring, Frank M. LaFerla, Nick Callamaras, Ian Parker
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2001-06-01
Collection:	Neurobiology of Disease
Sujets:	Alzheimer's disease calcium confocal microscopy endoplasmic reticulum phosphoinositide presenilin
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0969996101903821
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