Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a...

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Detalhes bibliográficos

Principais autores:	Samuel Peña-Díaz, Jordi Pujols, Francisca Pinheiro, Jaime Santos, Irantzu Pallarés, Susanna Navarro, María Conde-Gimenez, Jesús García, Xavier Salvatella, Esther Dalfó, Javier Sancho, Salvador Ventura
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-10-01
coleção:	Frontiers in Bioengineering and Biotechnology
Assuntos:	α-synuclein protein aggregation amyloid inhibitor Parkinson’s disease synucleinopathies small molecules
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fbioe.2020.588947/full
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