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Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na<sup>+</sup>,K<sup>+</sup>-ATPase α<sub>2</sub>-Isoform

Two α-isoforms of the Na<sup>+</sup>,K<sup>+</sup>-ATPase (α<sub>1</sub> and α<sub>2</sub>) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility. Mice heterozygous for the familial hemiplegic migraine type 2 (FHM2) associated muta...

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Principais autores: Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2023-04-01
Series:Cells
Assuntos:
Na<sup>+</sup>,K<sup>+</sup>-ATPase
α<sub>2</sub>-isoform
contractility
relaxation
ouabain
Langendorff
Acceso en liña:https://www.mdpi.com/2073-4409/12/8/1108
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