Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions

To address CD19 loss from lymphoma after anti-CD19 chimeric antigen receptor (CAR) T cell therapy, we designed a bicistronic construct encoding an anti-CD19 CAR and an anti-CD20 CAR. We detected deletions from the expected bicistronic construct sequence in a minority of transcripts by mRNA sequencin...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Norris Lam, Richard Finney, Shicheng Yang, Stephanie Choi, Xiaolin Wu, Lauren Cutmore, Jorge Andrade, Lei Huang, Christina Amatya, Margaret Cam, James N. Kochenderfer
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2023-09-01
Σειρά:	Molecular Therapy: Oncolytics
Θέματα:	retrovirus recombination sequence deletions chimeric antigen receptor CAR antigen-escape
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2372770523000475
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