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Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation

IntroductionModern histocompatibility algorithms depend on the comparison and analysis of high-resolution HLA protein sequences and structures, especially when considering epitope-based algorithms, which aim to model the interactions involved in antibody or T cell binding. HLA genotype imputation ca...

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Principais autores: Benedict M. Matern, Eric Spierings, Selle Bandstra, Abeer Madbouly, Stefan Schaub, Eric T. Weimer, Matthias Niemann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-09-01
Serier:Frontiers in Genetics
Fag:
imputation
HLA
epitope
PIRCHE
ancestry
bioinformatics
Online adgang:https://www.frontiersin.org/articles/10.3389/fgene.2024.1444554/full
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