Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction

Abstract Podophyllotoxin (PPT) is a naturally occurring plant-derived insecticide, yet its potent cytotoxicity raises concerns regarding potential neurobehavioral toxicity in non-target organisms. However, the underlying mechanisms remain largely unclear. This study aims to investigate the neurotoxi...

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Hlavní autoři:	Yi Ru, Ying Yu, Chuanxin Liu, Yunge Liu, Dongxia Liu, Ruyan Chen, Xiaowan Chen, Xiaoyang Bai, Tao Jiang, Jiajia Duan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-04-01
Edice:	BMC Microbiology
Témata:	Podophyllotoxin Neurotoxicity Zebrafish Purine metabolism Microbiota-gut-brain axis
On-line přístup:	https://doi.org/10.1186/s12866-026-05033-4
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