Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens

Abstract Background To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium. Methods Primary MSCs and ICAM-1-overexpressing MSCs (C3 cells) were gen...

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Autori principali:	Xin Li, Qian Wang, Li Ding, Yu-Xing Wang, Zhi-Dong Zhao, Ning Mao, Chu-Tse Wu, Hua Wang, Heng Zhu, Shou-Bin Ning
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-08-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Inflammatory bowel disease Mesenchymal stem cells Intercellular cell adhesion molecule-1 Homing
Accesso online:	http://link.springer.com/article/10.1186/s13287-019-1384-9
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