A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo

Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed as antitumor agents for orthotopic tumor. However, the serious side effects in cancer patients limit their applications. Herein, a new class of polyamine-based naphthalimide conjugates 5a-5c, 7a-7b, and 11a-11b...

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Principais autores:	Jing Ma, Yingguang Li, Linrong Li, Kexin Yue, Hanfang Liu, Jiajia Wang, Zhuoqing Xi, Man Shi, Sihan Zhao, Qi Ma, Sitong Liu, Shudi Guo, Jianing Liu, Lili Hou, Chaojie Wang, Peng George Wang, Zhiyong Tian, Songqiang Xie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-04-01
coleção:	Frontiers in Chemistry
Assuntos:	dinitro-naphthalimide conjugate polyamine polyamine transporter cancer minimized side-effects
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fchem.2020.00166/full
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