Pharmacochemical Studies of Synthesized Coumarin–Isoxazole–Pyridine Hybrids

Several new coumarin–isoxazole–pyridine hybrids were synthesized through a 1,3-dipolar cycloaddition reaction of nitrile oxides, prepared in situ from pyridine aldehyde oximes, with propargyloxy- or propargylaminocoumarins in moderate-to-good yields. Synthetic modifications were applied using (diace...

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Main Authors: Matina D. Douka, Ioanna M. Sigala, Catherine Gabriel, Eleni Nikolakaki, Dimitra J. Hadjipavlou-Litina, Konstantinos E. Litinas
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2025-04-01
Serija:Molecules
Teme:
coumarin–isoxazole–pyridine hybrid
1,3-dipolar cycloaddition reaction
propargyloxycoumarin
propargylaminocoumarin
pyridine aldehyde oxime
phenyliodine(III) diacetate (PIDA)
Online dostop:https://www.mdpi.com/1420-3049/30/7/1592
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