ASCT2 inhibits HIV-1 infectivity by promoting the incorporation of a gp160/ASCT2 complex into virions

ABSTRACT Restriction factors are type I interferon (IFN)-inducible proteins that provide an early line of defense against HIV-1. Our current findings propose the amino acid transporter ASCT2 as a new host plasma membrane transporter that restricts the infectivity of HIV-1 viral particles. Our result...

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Autors principals:	Luciana Morellatto Ruggieri, Eri Miyagi, Sandra Kao, Hideki Saito, Aymé Drake Figueredo, Haruki Kitamura, María I. Colombo, Klaus Strebel
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-08-01
Col·lecció:	mBio
Matèries:	ASCT2 restriction factor plasma membrane Vpu human immunodeficiency virus virus-host interactions
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.01465-25
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