Investigation of osteoprotegerin gene polymorphisms and serum level as a predictive marker of cardiac abnormalities in beta thalassemia major

Abstract Background Osteoprotegerin (OPG) is a protein that prevents excessive bone resorption by binding to its receptor, and its genetic variations may contribute to the development of cardiovascular disorders. Methods Eighty-two beta-thalassemia major patients of Sorour medical center of Mashhad,...

Полное описание

Библиографические подробности

Главные авторы:	Elham Pourrahim, Zahra Badiei, Hassan Mottaghi moghaddam shahri, Elham Mahmoudi, Mohammad Reza Keramati, hossein Ayatollahi, Fateme seyedmoharrami, Maryam sheikhi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	SpringerOpen 2026-06-01
Серии:	Egyptian Journal of Medical Human Genetics
Предметы:	Beta-thalassemia major Osteoprotegerin Echocardiography Single nucleotide polymorphisms Left ventricular hypertrophy Diastolic dysfunction
Online-ссылка:	https://doi.org/10.1186/s43042-026-00871-3
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