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The Effect of Alendronate on Osteoclastogenesis in Different Combinations of M-CSF and RANKL Growth Factors

Bisphosphonates (BPs) are compounds resembling the pyrophosphate structure. BPs bind the mineral component of bones. During the bone resorption by osteoclasts, nitrogen-containing BPs are released and internalized, causing an inhibition of the mevalonate pathway. As a consequence, osteoclasts are un...

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Autors principals: Věra Hedvičáková, Radmila Žižková, Matěj Buzgo, Michala Rampichová, Eva Filová
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2021-03-01
Col·lecció:Biomolecules
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Accés en línia:https://www.mdpi.com/2218-273X/11/3/438
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