Modulation of SIRT-1, NF-κB/TNF-α/IL-6, and ERK/Caspase-3 by Lutein Mitigates Methotrexate-Induced Hepatotoxicity

<b>Background/Objectives</b>: Methotrexate (MTX) is an effective immunosuppressant and chemotherapeutic agent used to manage various cancers and inflammatory illnesses, but its hepatotoxic hazards pose a major challenge to its clinical application. The preventive influence of lutein against MTX-elic...

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Autores principales:	Areej M. Abdelwahab, Heba A. Habib, Mostafa A. Darwish, Yousef A. Bin Jardan, Gehan H. Heeba
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-11-01
Colección:	Pharmaceuticals
Materias:	MTX lutein NF-κB SIRT-1 inflammation oxidative stress
Acceso en línea:	https://www.mdpi.com/1424-8247/18/12/1787
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