Titration of Androgen Signaling: How Basic Studies Have Informed Clinical Trials Using High-Dose Testosterone Therapy in Castrate-Resistant Prostate Cancer

Since the Nobel Prize-winning work of Huggins, androgen ablation has been a mainstay for treatment of recurrent prostate cancer. While initially effective for most patients, prostate cancers inevitably develop the ability to survive, grow, and metastasize further, despite ongoing androgen suppressio...

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Detalhes bibliográficos

Principais autores:	Steven K. Nordeen, Lih-Jen Su, Gregory A. Osborne, Perry M. Hayman, David J. Orlicky, Veronica M. Wessells, Adrie van Bokhoven, Thomas W. Flaig
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-08-01
coleção:	Life
Assuntos:	prostate cancer castrate-resistant prostate cancer androgens testosterone androgen receptor androgen signaling
Acesso em linha:	https://www.mdpi.com/2075-1729/11/9/884
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