Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway

Background Tetrahydrobiopterin (BH4) and its oxidized derivative dihydrobiopterin (BH2) were found to be strongly elevated in ME/CFS patients with orthostatic intolerance (ME + OI). Objective However, the molecular mechanism of biopterin biogenesis is poorly understood in ME + OI subjects. Here, we...

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Bibliografische Detailangaben

Hauptverfasser:	Sarojini Bulbule, Carl Gunnar Gottschalk, Molly E. Drosen, Daniel Peterson, Leggy A. Arnold, Avik Roy
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SAGE Publishing 2024-07-01
Schriftenreihe:	Journal of Central Nervous System Disease
Online-Zugang:	https://doi.org/10.1177/11795735241271675
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