High seroprevalence and high risk: why are older adults more prone to respiratory syncytial virus?

ABSTRACT Despite widespread seropositivity, respiratory syncytial virus (RSV) remains a major cause of severe illness in adults aged 60 years and older. This review examines why infection-acquired immunity fails to protect this group, focusing on four key factors: structural lung decline, comorbidit...

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Detalhes bibliográficos

Principais autores:	Piotr Rzymski, Barbara Poniedziałek, Dorota Zarębska-Michaluk, Krzysztof Tomasiewicz, Robert Flisiak
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-10-01
Colecção:	Journal of Virology
Assuntos:	respiratory syncytial virus immunosenescence prefusion F protein vaccination older adults antibody-dependent enhancement
Acesso em linha:	https://journals.asm.org/doi/10.1128/jvi.01432-25
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