Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

BackgroundExisting rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is gradually reduced, followed by subsequent progressi...

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Detalhes bibliográficos

Principais autores:	Yorito Hattori, Jun‐ichiro Enmi, Satoshi Iguchi, Satoshi Saito, Yumi Yamamoto, Masahiro Tsuji, Kazuyuki Nagatsuka, Rajesh N. Kalaria, Hidehiro Iida, Masafumi Ihara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2016-02-01
coleção:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	ameroid constrictor carotid artery stenosis mouse subcortical ischemic vascular dementia vascular cognitive impairment
Acesso em linha:	https://www.ahajournals.org/doi/10.1161/JAHA.115.002757
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