Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiolipin dissociation in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) displays mitochondrial dysfunction characterized by disrupted redox homeostasis and cristae disorganization, yet the underlying molecular mechanisms are unclear. We reveal that Src kinase phosphorylates prohibitin 2 (PHB2) at tyrosines Y34 and Y77 under oxidative stres...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Zhehua Shao, Xinnuo Yang, Binben Wang, Xuwen Wang, Duoduo Zhao, Bingchen Liu, Jinliang Nan
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2026-04-01
Цуврал:	Redox Biology
Нөхцлүүд:	Hepatocellular carcinoma (HCC) Mitochondrial cristae Cardiolipin Prohibitin Src-mediated phosphorylation Redox homeostasis
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2213231726000716
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!