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No difference in renal injury and fibrosis between wild-type and NOD1/NOD2 double knockout mice with chronic kidney disease induced by ureteral obstruction

Abstract Background Chronic kidney disease (CKD) is characterized by sustained tissue damage and ongoing tubulo-interstitial inflammation and fibrosis. Pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and NOD-like receptors (NLRs) can sense endogenous ligands released upon t...

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Main Authors: Ingrid Stroo, Diba Emal, Loes M. Butter, Gwen J. Teske, Nike Claessen, Mark C. Dessing, Stephen E. Girardin, Sandrine Florquin, Jaklien C. Leemans
Format: Artigo
Language:Inglês
Published: BMC 2018-04-01
Series:BMC Nephrology
Subjects:
Pattern recognition receptors
NOD1
NOD2
Renal fibrosis
Obstructive nephropathy
Online Access:http://link.springer.com/article/10.1186/s12882-018-0867-8
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