Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance

Tumorigenesis is commonly driven by genetic mutations and disruptions in cellular signalling pathways. Here we show that the oncogenic overexpression of the RNase L inhibitor ABCE1, a component of interferon signalling, leads to distinct and extensive deviations in cancer transcriptomes. RNase L is...

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Detalhes bibliográficos

Principais autores:	Edward Hitti, Tala Bakheet, Linah Mahmoud, Nada Al-Mutairi, Latifa Alhaj, Fahad Al-Zoghaibi, Khalid S. A. Khabar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
coleção:	RNA Biology
Assuntos:	ABCE1 RNase L colorectal adenocarcinoma lung adenocarcinoma UU/UA dinucleotides
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/15476286.2026.2629475
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