IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Summary: Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration. Deletion of IPMK diminishes autophagy in cell lines and mouse liver...

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Hlavní autoři:	Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2019-03-01
Edice:	Cell Reports
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124719301755
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