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An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

Abstract Background NSC260594, a quinolinium derivative from the NCI diversity set II compound library, was previously identified in a target-based assay as an inhibitor of the interaction between the HIV-1 (ψ) stem-loop 3 (SL3) RNA and Gag. This compound was shown to exhibit potent antiviral activi...

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Hoofdauteurs: Carin K. Ingemarsdotter, Jingwei Zeng, Ziqi Long, Andrew M.L. Lever, Julia C. Kenyon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2018-03-01
Reeks:Retrovirology
Onderwerpen:
HIV-1
Antiretroviral drugs
Packaging
RNA structure
Online toegang:http://link.springer.com/article/10.1186/s12977-018-0407-4
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