Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells

Introduction: Sarcopenia is defined as a loss of muscle mass and strength. ATP homeostasis is crucial during myogenesis. We determined how the purinergic system modulates myogenesis using dipyridamole (blocks adenosine taken up by the cells) and tenofovir (inhibits ATP release) in a myoblast cell li...

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Hlavní autoři:	Miguel Marco-Bonilla, Raquel Herencia, María Fresnadillo, Fernando Huete-Toral, Gonzalo Carracedo, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-09-01
Edice:	Frontiers in Pharmacology
Témata:	adenosine A2B receptor muscle sarcopenia dipyridamole
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1247664/full
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