Sequestration of Gβγ by deubiquitinated arrestins into the nucleus as a novel desensitization mechanism of G protein–coupled receptors

Abstract Background Desensitization of G protein–coupled receptors (GPCRs) refers to a rapid attenuation of responsiveness that occurs with repeated or continuous exposure to agonists. GRK-mediated phosphorylation and subsequent binding with arrestins in the activated receptor cytoplasmic cavity in...

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Hauptverfasser:	Xiao Min, Ningning Sun, Shujie Wang, Xiaohan Zhang, Kyeong-Man Kim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-01-01
Schriftenreihe:	Cell Communication and Signaling
Schlagworte:	Dopamine D2-like receptor β2 adrenoceptor Desensitization Src USP33 Nuclear trafficking
Online-Zugang:	https://doi.org/10.1186/s12964-022-01013-z
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