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The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

The catalytically inactive caspase-8-homologous protein, c-FLIP, is a potent antiapoptotic protein highly expressed in various types of cancers. c-FLIP competes with caspase-8 for binding to the adaptor protein FADD (Fas-Associated Death Domain) following death receptors’ (DRs) activation via the li...

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Hoofdauteurs: Katherine Yaacoub, Rémy Pedeux, Pierre Lafite, Ulrich Jarry, Samia Aci-Sèche, Pascal Bonnet, Richard Daniellou, Thierry Guillaudeux
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2024-01-01
Reeks:Current Issues in Molecular Biology
Onderwerpen:
c-FLIP
TRAIL
apoptosis
protein–protein interaction
drug resistance
cancer treatment
Online toegang:https://www.mdpi.com/1467-3045/46/1/46
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