Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling

Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-β/AMPK/SIRT-1/ERK-dependent mechanisms with unknown possible therapeutic applications...

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Autors principals:	Apiwan Arinno, Pichayapa Sukmak, Purisha Kulworasreth, Thaniya Sricharunrat, Chutima S. Vaddhanaphuti, Pawin Pongkorpsakol
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-01-01
Col·lecció:	Current Research in Pharmacology and Drug Discovery
Matèries:	Gallic acid Colitis Tight junction Intestinal barrier function Myosin light-chain kinase (MLCK)
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2590257125000112
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