Mitochondrial dysfunction in the pathogenesis of intervertebral disc herniation: a mitochondrial related genome-wide Mendelian randomization analysis

Abstract Background As a degenerative disease, the pathophysiology of intervertebral disc herniation (IDH) closely related to mitochondrial dysfunction. However, the specific molecular mechanisms involved have yet to be precisely established. Methods Here, we employed a two-sample, two-step Mendelia...

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Detalhes bibliográficos

Principais autores:	Yihao Wang, Yongchen Bie, Yun Zhang, Ying Huang, Kaili Wu, Xuexiao Ma, Yan Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Journal of Translational Medicine
Assuntos:	IDH Mitochondrial dysfunction Mendelian randomization Mitochondrial-related genes Genetic colocalization
Acesso em linha:	https://doi.org/10.1186/s12967-026-07851-6
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