Highly sensitive quantification of 7α-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS

We describe a highly sensitive and specific method for the quantification of serum 7α-hydroxy-4-cholesten-3-one (C4), which has been used as a biomarker for bile acid biosynthesis. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/...

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Autori principali:	Akira Honda, Kouwa Yamashita, Mitsuteru Numazawa, Tadashi Ikegami, Mikio Doy, Yasushi Matsuzaki, Hiroshi Miyazaki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2007-02-01
Serie:	Journal of Lipid Research
Soggetti:	bile acid synthesis cholesterol 7α-hydroxylase picolinic acid liquid chromatography electrospray ionization-tandem mass spectrometry
Accesso online:	http://www.sciencedirect.com/science/article/pii/S002222752043682X
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