Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis

IntroductionAs antibiotic resistance has become more prevalent, the social and economic impacts are increasingly pressing. Indeed, bacteria have developed the SOS response which facilitates the evolution of resistance under genotoxic stress. The transcriptional repressor, LexA, plays a key role in t...

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Autores principales:	Zachariah P. Schuurs, John P. McDonald, Laura V. Croft, Derek J. Richard, Roger Woodgate, Neha S. Gandhi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2023-03-01
Colección:	Frontiers in Cellular and Infection Microbiology
Materias:	LexA antibiotic resistance covalent inhibitors molecular docking proteolysis
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1051602/full
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