Targeting lncRNA MALAT1 attenuates lenalidomide resistance via CD38 epigenetic modulation, oxidative stress–mediated cell death, and remodeling of the pro-tumor microenvironment in multiple myeloma

Abstract Background Drug resistance remains a major challenge in multiple myeloma (MM). This study explores the role of the oncogenic long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in MM pathogenesis and lenalidomide resistance. Methods MALAT1 expression...

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Principais autores:	Wen-Hsin Chang, Wei-Ting Liao, Tsung-Jang Yeh, Sin-Hua Moi, Yi-Chang Liu, Hui-Hua Hsiao, Hui-Ching Wang, Jeng-Shiun Du, Yuh-Ching Gau, Ching-I Yang, Ching-Ping Lee, Chin-Mu Hsu, Shih-Feng Cho
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-10-01
叢編:	Journal of Translational Medicine
主題:	Multiple myeloma Long non-coding RNA MALAT1 CD38 OXPHOS pathway
在線閱讀:	https://doi.org/10.1186/s12967-025-07252-1
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