PDK4 drives abdominal aortic aneurysm by promoting smooth muscle cell metabolic reprogramming and NLRP3-mediated pyroptosis

Abstract Abdominal aortic aneurysm (AAA) is a progressive dilation of the abdominal aorta that can rupture and cause catastrophic internal bleeding, yet the mechanisms driving AAA remain poorly understood. Here we show that pyruvate dehydrogenase kinase 4 (PDK4), a key metabolic regulator, is upregu...

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Detalles Bibliográficos

Principais autores:	Li Zhao, Xuefeng Lin, Zhengqiang Zhu, Ranxin Liu, Lingna Zhao, Xuekun Wu, Mengru Zheng, Rihua Huang, Pengyu Zhou, Fangze Huang, Deshen Liu, Chuanjie Niu, Xiaoxia He, Zean Wang, Xin Li, Jiale Li, Shengping He, Jun Lu, Shaoyi Zheng, Jiaguo Zhou, Qinbao Peng, Xiu Liu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-04-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-026-71610-w
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