Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on genomic viral RNA that promote virion formation.

Bibliografiske detaljer

Principais autores:	Rebecca S. Brown, Dimitrios G. Anastasakis, Markus Hafner, Margaret Kielian
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2020-09-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-020-18447-z
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