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Novel benzimidazole-1, 3, 4-thiadiazole derivatives as casein kinase-2 inhibitors: synthesis, in vitro and in silico investigations

Abstract A new set of benzimidazole-thiadiazole derivatives has been designed and synthesized using 2-(chloromethyl)-1H-benzo[d]imidazole (1). Compounds 4a-m were achieved by amide bond formation using acid chlorides and pyridine in 1, 2-dichloroethane. The newly synthesized compounds were character...

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Bibliografische Detailangaben
Hauptverfasser: N. Senthilkumar, S. Sarveswari, Prafulla Choudhari, Somdatta Chaudhari, Imadul Islam, Yasinalli Tamboli, V. Vijayakumar
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-06-01
Schriftenreihe:BMC Chemistry
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Online-Zugang:https://doi.org/10.1186/s13065-025-01532-z
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