Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis.

The 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) enzymes catalyze sequential metabolic reactions in the folate biosynthetic pathway of bacteria and lower eukaryotes. Both enzymes represent validated targets for the development of novel anti-microbial...

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Principais autores:	Charles W Pemble, Perdeep K Mehta, Smriti Mehra, Zhenmei Li, Amanda Nourse, Richard E Lee, Stephen W White
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2010-11-01
Colecção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC2994781?pdf=render
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