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CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

Abstract The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive. Here, we showed that CEP55 overexpression/knockdown impacts surv...

Ausführliche Beschreibung

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Hauptverfasser: Murugan Kalimutho, Debottam Sinha, Jessie Jeffery, Katia Nones, Sriganesh Srihari, Winnie C Fernando, Pascal HG Duijf, Claire Vennin, Prahlad Raninga, Devathri Nanayakkara, Deepak Mittal, Jodi M Saunus, Sunil R Lakhani, J Alejandro López, Kevin J Spring, Paul Timpson, Brian Gabrielli, Nicola Waddell, Kum Kum Khanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Nature 2018-08-01
Schriftenreihe:EMBO Molecular Medicine
Schlagworte:
aneuploidy
breast cancer
centrosomal protein
CEP55
genomic instability
Online-Zugang:https://doi.org/10.15252/emmm.201708566
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