Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition

Monoclonal antibodies are playing an increasing role in both human and animal health. Different strategies of protein and chemical engineering, including humanization techniques of non-human antibodies were applied successfully to optimize clinical performances of antibodies. Despite the emergence o...

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Autores principales:	Mathieu Dondelinger, Patrice Filée, Eric Sauvage, Birgit Quinting, Serge Muyldermans, Moreno Galleni, Marylène S. Vandevenne
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2018-10-01
Colección:	Frontiers in Immunology
Materias:	numbering scheme complementary determining regions antibody humanization antigen binding residue antibody engineering
Acceso en línea:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02278/full
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