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AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Abstract In the frame of radiotherapy treatment of cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve the radiosensitivity of tumors and reduce the damage of radiation to neighboring normal tissues, radiosensitizers have been given increas...

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Principais autores: Hao Sun, Hui Cai, Chang Xu, Hezheng Zhai, François Lux, Yi Xie, Li Feng, Liqing Du, Yang Liu, Xiaohui Sun, Qin Wang, Huijuan Song, Ningning He, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Géraldine Leduc, Tristan Doussineau, Yan Wang, Qiang Liu, Olivier Tillement
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-10-01
coleção:Journal of Nanobiotechnology
Assuntos:
Radiosensitization
Ferroptosis
Peroxide
DNA damage repair
AGuIX nanoparticles
Acesso em linha:https://doi.org/10.1186/s12951-022-01654-9
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