NDC80 promotes epithelial to mesenchymal transition of esophageal squamous cell carcinoma through macrophages polarization and PI3K/AKT pathway activation

Abstract Objective Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy with limited therapeutic options, primarily due to its aggressive metastatic behavior. This study aimed to elucidate the molecular drivers of ESCC metastasis by identifying a critical oncogene and investigate its fun...

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Detalhes bibliográficos

Principais autores:	Jiao Shu, Chenbo Yang, Zexin Sun, Yinghao Liang, Na Zhao, Xiaonan Liu, Yiwei Li, Muhammad Saud Tabish, Miaomiao Sun, Kuisheng Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	European Journal of Medical Research
Assuntos:	Esophageal squamous cell carcinoma NDC80 Epithelial-mesenchymal transition Tumor-associated macrophages PI3K/AKT
Acesso em linha:	https://doi.org/10.1186/s40001-025-03397-3
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