Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages

During liver injury, intrahepatic macrophage compartment is augmented by circulating monocytes that infiltrate the liver driven by C–C motif chemokine ligand/C–C motif chemokine receptor (CCL/CCR) axis including CCL1‒CCR8 axis, thereby contributing to liver inflammation. Numerous small molecular rec...

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Detalhes bibliográficos

Principais autores:	Eline Geervliet, Sahil Arora, Dagmara Donohue, Carlos Antonio de Albuquerque Pinheiro, Leon W.M.M. Terstappen, Richard Schasfoort, Julieta Paez, Raj Kumar, Ruchi Bansal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-04-01
coleção:	Acta Pharmaceutica Sinica B
Assuntos:	CCL1‒CCR8 axis Intrahepatic monocyte infiltration and differentiation Liver inflammation CCR8 antagonizing peptide In silico molecular docking In vitro chemotaxis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383525000942
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