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An epigenome-wide association study of sex-specific chronological ageing

Abstract Background Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown to be associated with both age and sex. Here, we i...

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Principais autores: Daniel L. McCartney, Futao Zhang, Robert F. Hillary, Qian Zhang, Anna J. Stevenson, Rosie M. Walker, Mairead L. Bermingham, Thibaud Boutin, Stewart W. Morris, Archie Campbell, Alison D. Murray, Heather C. Whalley, David J. Porteous, Caroline Hayward, Kathryn L. Evans, Tamir Chandra, Ian J. Deary, Andrew M. McIntosh, Jian Yang, Peter M. Visscher, Allan F. McRae, Riccardo E. Marioni
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-12-01
coleção:Genome Medicine
Assuntos:
DNA methylation
Ageing
Sexual dimorphism
X chromosome
Generation Scotland
Acesso em linha:https://doi.org/10.1186/s13073-019-0693-z
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