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Timing and intensity of proton pump inhibitor exposure hampers overall survival in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors: a retrospective cohort study

IntroductionProton pump inhibitor (PPI) use has been associated with reduced immune checkpoint inhibitor (ICI) efficacy in metastatic non-small cell lung cancer (mNSCLC) with evidence limited to their use during a short time period around ICI initiation. This study evaluated the associations between...

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Principais autores: Nuša Japelj, Nejc Horvat, Janja Jazbar, Mitja Kos, Veronika Pelicon Kapušin, Lea Knez
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Immunology
Assuntos:
carcinoma
non-small-cell lung
immune checkpoint inhibitors
proton pump inhibitors
survival analysis
gastrointestinal microbiome
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1682723/full
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