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Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure

Cholesteryl ester transfer protein (CETP) catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in modulating plasma HDL cholesterol levels in humans is well established and there have been significant efforts to develop...

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Principais autores: Guoqing Cao, Thomas P. Beyer, Youyan Zhang, Robert J. Schmidt, Yan Q. Chen, Sandra L. Cockerham, Karen M. Zimmerman, Sotirios K. Karathanasis, Ellen A. Cannady, Todd Fields, Nathan B. Mantlo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2011-12-01
Serier:Journal of Lipid Research
Fag:
CETP
cholesterol
cholesterol/metabolism
drug therapy
lipoproteins/metabolism
Online adgang:http://www.sciencedirect.com/science/article/pii/S0022227520408211
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