Computational identification and evaluation of novel PD-L1 inhibitors for cancer immunotherapy

Abstract Antibody-based therapies targeting the PD-1/PD-L1 pathway have shown promise in anticancer immunotherapy; however, challenges such as high cost, immunogenicity, and limited penetration highlight the need for small-molecule inhibitors. To find new inhibitors, this study used the ligand found...

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書誌詳細

主要な著者:	Hina Manzoor, Muhammad Umer Khan, Chaudhry Ahmed Shabbir, Raima Rehman, Alaa S. Alhegaili, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Ayman Ali Mohammed Alameen
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-09-01
シリーズ:	Scientific Reports
主題:	Cancer Immunotherapy PD-L1 LBVS Molecular docking Molecular dynamics
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-01232-7
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