Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein

Abstract Background The Gram-positive Streptomyces lividans TK24 is an attractive host for heterologous protein production because of its high capability to secrete proteins—which favors correct folding and facilitates downstream processing—as well as its acceptance of methylated DNA and its low end...

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Detalles Bibliográficos

Principais autores:	Wouter Daniels, Jeroen Bouvin, Tobias Busche, Christian Rückert, Kenneth Simoens, Spyridoula Karamanou, Lieve Van Mellaert, Ólafur H. Friðjónsson, Bart Nicolai, Anastassios Economou, Jörn Kalinowski, Jozef Anné, Kristel Bernaerts
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2018-12-01
Series:	Microbial Cell Factories
Assuntos:	Streptomyces lividans Heterologous protein production and secretion $$^{13}\hbox {C}$$ 13 C -based metabolic flux RNA-seq analysis Gene clustering analysis
Acceso en liña:	http://link.springer.com/article/10.1186/s12934-018-1040-6
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