α-Latrotoxin Tetramers Spontaneously Form Two-Dimensional Crystals in Solution and Coordinated Multi-Pore Assemblies in Biological Membranes

α-Latrotoxin (α-LTX) was found to form two-dimensional (2D) monolayer arrays in solution at relatively low concentrations (0.1 mg/mL), with the toxin tetramer constituting a unit cell. The crystals were imaged using cryogenic electron microscopy (cryoEM), and image analysis yielded a ~12 Å projectio...

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Principais autores:	Alexis Rohou, Edward P. Morris, Julia Makarova, Alexander G. Tonevitsky, Yuri A. Ushkaryov
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2024-05-01
丛编:	Toxins
主题:	α-latrotoxin cryo-electron microscopy two-dimensional crystals membrane pore formation
在线阅读:	https://www.mdpi.com/2072-6651/16/6/248
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